Personally I have Twhirl running in my background on my computer and when I want to update I just open it up and type in something and hit send which sends my, "Just ate an apple and now I'm going to blog" update to everyone following me.
Twitter is like an influx of text message hitting your desktop from all your friends and followers. It's the best! I'm following celebrities, box buyers, advertisers, and some who live the most thrilling lives!
You'll find me on Twitter by searching for LittleBlackBox or even clicking this link.